For tropes related to Isaac as the boss enemy of the Cathedral, please go to the section on final bosses. Beating the game in certain ways or collecting certain items unlocks variations of Isaac with their own unique attributes.įor tropes related to Isaac and his alter-egos in gameplay, scroll down to the section on player characters. A little boy who flees into the basement of his house to escape from his mother who wants to kill him, and must fight for his life against a never-ending assortment of demons and mutants.
